Job Title: Associate Scientist/Scientist – Antibody Engineering

Location: Rockville, MD (Onsite)

Hours/Schedule: Monday-Friday, core hours 8:00 AM – 5:00 PM (some flexibility)

Compensation: $30-$40/hour

Type: Contract (6 months) with potential for extension

Overview
Leading biotechnology organization is seeking a Associate Scientist/Scientist, Antibody Engineering to support antibody discovery and engineering programs. This role offers hands-on involvement in the design, optimization, and evaluation of monoclonal and bispecific antibodies using modern molecular biology and immunoassay techniques. This is a high-impact opportunity to contribute directly to early-stage biologics development in a collaborative research environment.

Responsibilities

• Design, engineer, and evaluate monoclonal and bispecific antibodies using molecular biology techniques
• Construct and optimize multiple antibody formats to improve affinity, stability, and developability
• Perform and analyze immunoassays, including ELISA, to assess antibody function, stability, and serum clearance
• Evaluate antibody performance using analytical platforms such as ELISA, flow cytometry, and Octet
• Support experimental design, data analysis, and interpretation to guide antibody optimization strategies
• Document experimental procedures, results, and conclusions in accordance with internal standards
• Collaborate cross-functionally with scientists to advance antibody engineering projects toward development goals

Requirements

• Bachelor’s degree in a scientific discipline with 2-5 years of related experience OR; Master’s degree in a scientific discipline with 1-3 years of related experience
• Strong background in molecular biology techniques, including molecular cloning, RNA isolation, mutagenesis (QuikChange), and sequencing analysis
• Hands-on experience performing immune-binding assays such as ELISA
• Experience using software tools for plasmid mapping and sequence analysis (e.g., SnapGene) and ELISA data analysis (e.g., SoftMax, GraphPad Prism, Excel)
• Ability to work collaboratively in a fast-paced, research-driven environment
• Must be legally authorized to work in the United States for any employer

Benefits
System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.

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Ref: #558-Scientific